Compared with NSAIDs, acetaminophen is not associated with which adverse effect?

Compared with NSAIDs, acetaminophen is not associated with which adverse effect?

• A. Gastrointestinal irritation
• B. Liver toxicity
• C. Fever reduction
• D. Analgesia

Answer: (A)

Gastrointestinal irritation is primarily linked to NSAIDs because these drugs inhibit COX-1, reducing protective gastric prostaglandins and increasing the risk of gastritis, ulcers, and bleeding. Acetaminophen, on the other hand, does not significantly irritate the gastric mucosa, so GI irritation is not a typical adverse effect associated with it. Be aware that acetaminophen can cause liver toxicity in overdose, which is a real risk, and it provides analgesia and fever reduction—effects shared with NSAIDs, not adverse effects.

Gastrointestinal irritation is primarily linked to NSAIDs because these drugs inhibit COX-1, reducing protective gastric prostaglandins and increasing the risk of gastritis, ulcers, and bleeding. Acetaminophen, on the other hand, does not significantly irritate the gastric mucosa, so GI irritation is not a typical adverse effect associated with it.

Be aware that acetaminophen can cause liver toxicity in overdose, which is a real risk, and it provides analgesia and fever reduction—effects shared with NSAIDs, not adverse effects.